Literature summary extracted from

Yang, W.; Han, W.; Ye, S.; Liu, D.; Wu, J.; Liu, H.; Li, C.; Chen, H.
Fibroblast activation protein-alpha promotes ovarian cancer cell proliferation and invasion via extracellular and intracellular signaling mechanisms (2013), Exp. Mol. Pathol., 95, 105-110.

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
3.4.21.B28	extracellular	the enzyme is secreted	Homo sapiens	-	-

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.21.B28	Homo sapiens	Q12844	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.21.B28	fibroblast	activated stromal fibroblasts	Homo sapiens	-
3.4.21.B28	HO-8910PM cell	-	Homo sapiens	-
3.4.21.B28	ovary cancer cell	-	Homo sapiens	-

Synonyms

EC Number	Synonyms	Comment	Organism
3.4.21.B28	FAPalpha	-	Homo sapiens
3.4.21.B28	fibroblast activation protein-alpha	-	Homo sapiens

General Information

EC Number	General Information	Comment	Organism
3.4.21.B28	physiological function	fibroblast activation protein-alpha promotes ovarian cancer cell proliferation and invasion via extracellular and intracellular signaling mechanisms, role of the non-enzymatic activities of the enzyme, overview. The enzyme, together with integrin alpha3beta1 and the uPAR signaling complex, mediates cancer cell migration in the HO-8910PM cell line via the small GTPase Rac1. FAP?-mediated upregulation of p-ERK occurs in a time-dependent manner	Homo sapiens

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Release 2023.1 (January 2023)